STEPHEN DAVIS, M.D.; PIETRO RAMBOTTI, M.D.; FAUSTO GRIGNANI, M.D.; KENNETH STEINHOUSE, M.D.
To the editor: Microangiopathic hemolytic anemia (1) is a rare but well-documented complication of malignant diseases. According to Horne and Cooper (2) only 59 cases have been reported, almost exclusively with adenocarcinomas (2), most commonly (50%) gastric but also breast, pancreatic, ovarian, prostatic and colonic. Only seven possible cases of this complication have been associated with bronchogenic carcinoma, and none with small-cell characteristics (2, 3). In the last 8 years we have seen 3 cases associated with biopsy-proven small-cell carcinoma of the lung.
The peripheral blood smears of 167 consecutive patients with newly diagnosed small-cell carcinoma were reviewed for microangiopathic
DAVIS S, RAMBOTTI P, GRIGNANI F, STEINHOUSE K. Microangiopathic Hemolytic Anemia and Pulmonary Small-Cell Carcinoma. Ann Intern Med. ;103:638. doi: 10.7326/0003-4819-103-4-638_1
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Published: Ann Intern Med. 1985;103(4):638.
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