ELLEN D. BURGESS, M.D.; LAWRENCE P. SCHNURR, M.D.; PETER WILKES, Ph.D.
To the editor: We were interested in the recent article by Anderson and colleagues (1) on the prevalence and prognosis of hyponatremia in hospitalized patients and write to offer some comments.
We have recently found a systematic overestimation of serum sodium concentration as measured by an ion-selective electrode analyzer (Kodak Ektachem 400 Analyzer; Eastman Kodak Co., Rochester, New York) as compared with flame photometric determination (FLM 3 Flame Photometer; Radiometer, Copenhagen, Denmark). The overestimation is proportionate to the degree of hypoproteinemia, with discrepancy as great as 10 meq/L at total serum protein concentrations of 4 to 5 g/dL. The cause
BURGESS ED, SCHNURR LP, WILKES P. Ion-Selective Electrodes and Inaccurate Serum Sodium Measurements. Ann Intern Med. ;103:806. doi: 10.7326/0003-4819-103-5-806_1
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Published: Ann Intern Med. 1985;103(5):806.
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