WILLIAM J. MEGGS, M.D., Ph.D.; MARIANNE FRIERI, M.D., Ph.D.; RENE COSTELLO, B.S.; DEAN D. METCALFE, M.D.; NICHOLAS M. PAPADOPOULOS, Ph.D.
Mastocytosis is defined as a disease in which mast cells infiltrate one or more tissues. Mastocytosis may be either benign or malignant (1), with the benign form of the disease characterized by a protracted, indolent course. Persons with benign mastocytosis are at increased risk for developing hematologic malignancies and also a malignant form of mastocytosis (2, 3).The recognition of malignancy in mastocytosis may be difficult, as the signs of malignancy can be obscured by, or confused with, the abnormalities associated with benign mastocytosis. Because in recent studies oligoclonal immunoglobulins have been found in the sera of patients with certain malignancies
MEGGS WJ, FRIERI M, COSTELLO R, METCALFE DD, PAPADOPOULOS NM. Oligoclonal Immunoglobulins in Mastocytosis. Ann Intern Med. ;103:894–895. doi: 10.7326/0003-4819-103-6-894
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Published: Ann Intern Med. 1985;103(6_Part_1):894-895.
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