GIUSEPPE CARPENTIERE, M.D.; SALVATORE MARINO, M.D.; FRANCESCO CASTELLO, M.D.
To the editor: The difficulty in maintaining stable around-the-clock serum theophylline concentrations is a well-recognized problem among clinicians caring for patients with asthma (1). Many factors can cause wide swings in the serum theophylline concentrations, including interactions with other drugs (2).
In our experience furosemide has also shown this possible effect in eight patients with chronic stable asthma (age range, 28 to 46 years). None of them was receiving adrenal corticosteroids or other medications. Dietary xanthines were withheld for 72 hours before each study day. After overnight fast on separate days, each patient received 300 mg of sustained-release theophylline together
CARPENTIERE G, MARINO S, CASTELLO F. Furosemide and Theophylline. Ann Intern Med. ;103:957. doi: 10.7326/0003-4819-103-6-957_2
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Published: Ann Intern Med. 1985;103(6_Part_1):957.
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