E. J. P. BROMMER; P. VAN BRUMMELEN; F. H. M. DERKX
To the editor: In the review on desmopressin in the August issue (1), the scarcity of side effects is justly emphasized. Presumably because of the low dose administered, few investigators seem to have noticed the potent hypotensive capacity of the drug, which reveals itself only when desmopressin is infused intravenously. Facial flushing and a feeling of warmth reflect the vasodilatory action. A drop in diastolic blood pressure of about 14 mm Hg and an increase in heart rate of 20 beats/min are the rule during intravenous infusion of desmopressin in a dosage of 0.4 µg/kg body weight or more (2-4).
BROMMER EJP, VAN BRUMMELEN P, DERKX FHM. Desmopressin and Hypotension. Ann Intern Med. ;103:962. doi: 10.7326/0003-4819-103-6-962_1
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Published: Ann Intern Med. 1985;103(6_Part_1):962.
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