ABIGAIL ZUGER, M.D.; EDDIE LOUIE, M.D.; ROBERT S. HOLZMAN, M.D.; MICHAEL S. SIMBERKOFF, M.D.; JAMES J. RAHAL, M.D.
Between 1 January 1981 and 1 December 1984, 34 of 396 patients with the acquired immunodeficiency syndrome (AIDS) developed cryptococcal infections. Twenty-six cases are reviewed. Twenty-two patients had brain or meningeal disease; the others had pulmonary disease (2 patients), pericarditis (1 patient), and antigenemia (1 patient). During treatment, 3 patients died of cryptococcosis and 3 died of other causes. Fifteen patients were followed for more than 6 weeks after treatment. Of 8 patients who received no additional amphotericin B, 4 had relapses and died of cryptococcosis within 6 months, 3 died of other causes, and 1 survived. Of 7 patients who received maintenance therapy with amphotericin B, none had relapses, 3 died of other causes, and 4 survived. Our data suggest that maintenance therapy with amphotericin may be needed to prevent relapse in patients with AIDS.
ZUGER A, LOUIE E, HOLZMAN RS, SIMBERKOFF MS, RAHAL JJ. Cryptococcal Disease in Patients with the Acquired Immunodeficiency Syndrome: Diagnostic Features and Outcome of Treatment. Ann Intern Med. ;104:234–240. doi: 10.7326/0003-4819-104-2-234
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Published: Ann Intern Med. 1986;104(2):234-240.
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