CHARLES P. TALIERCIO, M.D.; RONALD E. VLIETSTRA, M.B., Ch.B.; LLOYD D. FISHER, Ph.D.; JOHN C. BURNETT, M.D.
In 139 patients with preexisting abnormal renal function (serum creatinine level of 2.0 mg/dL or greater) undergoing cardiac angiography (141 examinations), the incidence of contrast nephropathy, defined as a 1 mg/dL or greater rise in serum creatinine, was 23% (95% confidence interval, 17% to 30%). Stepwise logistic regression analysis showed that contrast nephropathy was independently associated with class IV heart failure with low cardiac output (71% incidence in this subgroup; p < 0.0001), multiple radiocontrast studies within 72 hours (50%; p = 0.002), dose of radiocontrast administered (p = 0.009), and insulin-dependent diabetes mellitus (44%; p = 0.007). Age, hypertension, and hyperuricemia were not associated. In patients without low cardiac output, other radiocontrast tests, or insulin-dependent diabetes mellitus, there was a 2% incidence of contrast nephropathy in those who received less than 125 mL radiocontrast and a 19% incidence in those who received 125 mL or greater.
CHARLES P. TALIERCIO, RONALD E. VLIETSTRA, LLOYD D. FISHER, JOHN C. BURNETT. Risks for Renal Dysfunction with Cardiac Angiography. Ann Intern Med. 1986;104:501–504. doi: 10.7326/0003-4819-104-4-501
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Published: Ann Intern Med. 1986;104(4):501-504.
Cardiac Diagnosis and Imaging, Cardiology, Nephrology.
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