MICHAEL C. BACH, M.D.
To the editor: Two patients whose cases were described in our article in the September issue (1) have developed breakthrough cytomegalovirus infection.
Patient 1 began to develop weight loss, malaise, and anorexia during his sixth month of once-daily maintenance therapy with 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) (5 mg/kg body weight). Blood, throat, and urine cultures all grew cytomegalovirus after a 4-month interval of negative cultures. He was noted to have new areas of retinitis and developed increasing cough, shortness of breath, and chest tightness. He refused to be rehospitalized for full-dose therapy and requested withdrawal of all therapy. Four days after his
BACH MC. Breakthrough of Cytomegalovirus Infection Despite 9-(1,3-Dihydroxy-2-propoxymethyl)guanine Therapy. Ann Intern Med. ;104:587. doi: 10.7326/0003-4819-104-4-587_2
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Published: Ann Intern Med. 1986;104(4):587.
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