WILLIAM L. WOLFSON, M.D.
To the editor: I am delighted that a series on diagnostic testing is underway, but a point in the first article (1), on carcinoembryonic antigen, needs clarification.
Dr. Fletcher refers to a Dukes "D" lesion. There is no such animal. In the first Dukes classification (2), rectal carcinomas were classified as A, B, or C. This list was subsequently modified (3) to include C1 and C2 lesions, which differ in the location of positive node groups. Others have since added groups and changed Sir Cuthbert's original definitions, but it behooves us to use the Dukes classes correctly if we use
WOLFSON WL. Carcinoembryonic Antigen. Ann Intern Med. ;104:724. doi: 10.7326/0003-4819-104-5-724_1
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Published: Ann Intern Med. 1986;104(5):724.
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