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Early recognition of interferon's potential usefulness in human disease stemmed from its extraordinary potency on a weight basis and its broad spectrum of antiviral, antiproliferative, and immunoregulatory activities. The application of recombinant DNA technology yielded several interferons purified almost to homogeneity and in seemingly limitless quantity. Hundreds of clinical trials followed in the United States and in Europe, primarily of its use in neoplastic disorders but also in a variety of viral and other infectious diseases. One or more alpha-interferons will probably be marketed in the summer of 1986. This book is therefore a timely synthesis of the experimental and
Interferons: Their Impact in Biology and Medicine.. Ann Intern Med. ;104:735–736. doi: 10.7326/0003-4819-104-5-735_3
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Published: Ann Intern Med. 1986;104(5):735-736.
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