ELISABETH PAIETTA, Ph.D.; BRIAN SALTZMAN, M.D.; ROBERT S. KLEIN, M.D.; GERALD H. FRIEDLAND, M.D.; PETER H. WIERNIK, M.D.; HARALD STEIN, M.D.
To the editor: Since the demonstration that the human T-lymphotropic virus type III/lymphadenopathy virus (HTLV-III/LAV) is the likely cause of the acquired immunodeficiency syndrome (AIDS), it has become clear that susceptibility to, and clinical outcome from, infection vary. Among high-risk groups, not all persons are infected, and among those infected there appears to be a spectrum from apparently healthy through AIDS-related complex to AIDS (1). The reasons for certain exposed persons acquiring infection and for some infected persons becoming ill are not yet known.
One cofactor postulated to be important is the activation of the immune system (2, 3). The
PAIETTA E, SALTZMAN B, KLEIN RS, FRIEDLAND GH, WIERNIK PH, STEIN H. Expression of Activation Antigen on Lymphocytes in the Acquired Immunodeficiency Syndrome. Ann Intern Med. ;104:890–891. doi: 10.7326/0003-4819-104-6-890_2
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Published: Ann Intern Med. 1986;104(6):890-891.
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