SHIH-TZER TSAI, M.D.; AARON I. VINIK, M.D.; JOHN F. BRUNNER, M.D.
To the editor: Somatostatin (1) and its synthetic analogs have been shown to reduce diarrhea in patients with short bowel syndrome (2), ileostomy (3), and tumor-induced secretory diarrhea (4). We describe the effect of a new, long-acting somatostatin analog, SMS 201-995 (Sandoz Inc., East Hanover, New Jersey), on diarrhea refractory to all forms of therapy in an insulin-dependent diabetic patient with autonomic neuropathy (5) and a 10-year history of intermittent loose bowel movements.
A 39-year-old woman with poorly controlled diabetes for 17 years was admitted with profuse, painless, watery diarrhea that had lasted 15 months and was unresponsive to treatment.
SHIH-TZER TSAI, AARON I. VINIK, JOHN F. BRUNNER. Diabetic Diarrhea and Somatostatin. Ann Intern Med. 1986;104:894. doi: 10.7326/0003-4819-104-6-894_1
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Published: Ann Intern Med. 1986;104(6):894.
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