SHIH-TZER TSAI, M.D.; AARON I. VINIK, M.D.; JOHN F. BRUNNER, M.D.
To the editor: Somatostatin (1) and its synthetic analogs have been shown to reduce diarrhea in patients with short bowel syndrome (2), ileostomy (3), and tumor-induced secretory diarrhea (4). We describe the effect of a new, long-acting somatostatin analog, SMS 201-995 (Sandoz Inc., East Hanover, New Jersey), on diarrhea refractory to all forms of therapy in an insulin-dependent diabetic patient with autonomic neuropathy (5) and a 10-year history of intermittent loose bowel movements.
A 39-year-old woman with poorly controlled diabetes for 17 years was admitted with profuse, painless, watery diarrhea that had lasted 15 months and was unresponsive to treatment.
TSAI S, VINIK AI, BRUNNER JF. Diabetic Diarrhea and Somatostatin. Ann Intern Med. ;104:894. doi: 10.7326/0003-4819-104-6-894_1
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Published: Ann Intern Med. 1986;104(6):894.
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