A. SACERDOTE, M.D.
To the editor: I read with interest the article by Fedorak and associates (1) on treatment of diabetic diarrhea with clonidine. I recently used topical clonidine (Catapres TTs1; Boehringer-Ingelheim, Ridgefield, Connecticut) to treat a 50-year-old woman who had diabetic diarrhea refractory to anticholinergicopiate (Lomotil; Searle & Co., San Juan, Puerto Rico) and to kaolin-pectin (Kaopectate, The Upjohn Company, Kalamazoo, Michigan) treatment alone and in combination.
Before use of topical clonidine, she had 15 to 20 stools per day that were liquid to semisolid. While using clonidine she had well-formed stools, and unlike the patients described in the report by Fedorak
SACERDOTE A. Topical Clonidine for Diabetic Diarrhea. Ann Intern Med. ;105:139. doi: 10.7326/0003-4819-105-1-139_1
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Published: Ann Intern Med. 1986;105(1):139.
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