PETER S. HEEGER, M.D.; JAY T. BACKSTROM, M.D.
To the editor: Heparin-induced thrombocytopenia, with or without arterial thrombi, has been described as occurring with full-dose intravenous heparin treatment, as well as low-dose subcutaneous treatment (1, 2). We report a case of heparin-induced thrombocytopenia from heparin flushes (< 500 U/d).
A 73-year-old man was admitted for evaluation of anuric renal failure. A diagnosis of antiglomerular basement membrane disease was eventually made by renal biopsy. During the evaluation the patient became thrombocytopenic, with the platelet count decreasing from 541000 to 50 000/mm3 over 8 to 10 days. He had no evidence of sepsis, disseminated intravascular coagulation, or thrombotic thrombocytopenic purpura
HEEGER PS, BACKSTROM JT. Heparin Flushes and Thrombocytopenia. Ann Intern Med. ;105:143. doi: 10.7326/0003-4819-105-1-143_1
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Published: Ann Intern Med. 1986;105(1):143.
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