ROBERT L. JACOBS, M.D.; RICHARD E. THORNER, M.D.; JOHN R. HOLCOMB, M.D.; LEIGH ANNE SCHWIETZ, M.D.; FRANK O. JACOBS, B.S.
A 48-year-old woman had an 18-month history of malaise and chronic cough with intermittent episodes of fever, chills, and pneumonic infiltrates. Transbronchial biopsy findings were consistent with hypersensitivity pneumonitis. Cultures of fungus from a hot-tub room in her home were positive for Cladosporium species. Serum precipitins were weakly positive for Cladosporium cladosporioides. Removal of the patient from the home environment led to a resolution of symptoms within 1 week. Within 4 hours of re-exposure to the hot-tub room, symptoms and signs and changes in leukocyte count and spirometric values again occurred. Bronchial provocation with a commercial extract of C. cladosporioides led to a similar pattern 5 hours after the initial challenge. This case identifies a previously unreported etiologic agent and environmental site for hypersensitivity pneumonitis.
ROBERT L. JACOBS, RICHARD E. THORNER, JOHN R. HOLCOMB, LEIGH ANNE SCHWIETZ, FRANK O. JACOBS. Hypersensitivity Pneumonitis Caused by Cladosporium in an Enclosed Hot-Tub Area. Ann Intern Med. 1986;105:204. doi: 10.7326/0003-4819-105-2-204
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Published: Ann Intern Med. 1986;105(2):204.
Infectious Disease, Interstitial Lung Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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