ROBERT L. JACOBS, M.D.; RICHARD E. THORNER, M.D.; JOHN R. HOLCOMB, M.D.; LEIGH ANNE SCHWIETZ, M.D.; FRANK O. JACOBS, B.S.
A 48-year-old woman had an 18-month history of malaise and chronic cough with intermittent episodes of fever, chills, and pneumonic infiltrates. Transbronchial biopsy findings were consistent with hypersensitivity pneumonitis. Cultures of fungus from a hot-tub room in her home were positive for Cladosporium species. Serum precipitins were weakly positive for Cladosporium cladosporioides. Removal of the patient from the home environment led to a resolution of symptoms within 1 week. Within 4 hours of re-exposure to the hot-tub room, symptoms and signs and changes in leukocyte count and spirometric values again occurred. Bronchial provocation with a commercial extract of C. cladosporioides led to a similar pattern 5 hours after the initial challenge. This case identifies a previously unreported etiologic agent and environmental site for hypersensitivity pneumonitis.
JACOBS RL, THORNER RE, HOLCOMB JR, SCHWIETZ LA, JACOBS FO. Hypersensitivity Pneumonitis Caused by Cladosporium in an Enclosed Hot-Tub Area. Ann Intern Med. ;105:204. doi: 10.7326/0003-4819-105-2-204
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Published: Ann Intern Med. 1986;105(2):204.
Infectious Disease, Interstitial Lung Disease, Pulmonary/Critical Care.
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