PETER W. STACPOOLE, Ph.D, M.D.
Lactic acidosis is perhaps the commonest and most poorly treated acid-base disorder. If a blood lactate concentration of at least 5 meq/L (5 mmol/L) and an arterial pH of 7.2 or less are the criteria, the reported incidence of lactic acidosis among adult hospitalized patients not having surgery is about 1% (1). Approximately 60% to 70% of all patients with lactic acidosis die (1, 2) and, among those in whom hypotension coexists, mortality approaches 100% (3-6).Based on these statistics alone, the conclusion is inescapable that present therapy for lactic acidosis is inadequate. Not as readily apparent, however, is whether any
STACPOOLE PW. Lactic Acidosis: The Case Against Bicarbonate Therapy. Ann Intern Med. ;105:276–279. doi: 10.7326/0003-4819-105-2-276
Download citation file:
Published: Ann Intern Med. 1986;105(2):276-279.
Endocrine and Metabolism.
Results provided by:
Copyright © 2018 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use