ALVIN H. MOSS, M.D.; RILEY ROGER, M.D.; ANTHONY MURGO, M.D.; LEE ANN SKAFF, M.D.
To the editor: The availability of ibuprofen (Advil Whitehall Laboratories, New York, New York; and Nuprin, Bristol-Myers Products, New York, New York) as an over-the-counter medication has caused concern because of its many nephrotoxic effects (1). We call attention to the combined effects of volume depletion from influenza and ingestion of aspirin and ibuprofen in inducing acute renal failure.
A previously healthy 43-year-old man developed symptoms of influenza (nausea, vomiting, fever, malaise, and myalgias) and took Advil, 200 mg three times a day for 2 days, at the recommendation of his pharmacist after aspirin had failed to alleviate this myalgias.
MOSS AH, ROGER R, MURGO A, SKAFF LA. Over-the-Counter Ibuprofen and Acute Renal Failure. Ann Intern Med. 1986;105:303. doi: 10.7326/0003-4819-105-2-303_2
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Published: Ann Intern Med. 1986;105(2):303.
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