JOHN V. BORDERS, M.D.
To the editor: Captopril is usually well tolerated but has been associated with rash, dysgeusia, and, rarely, hematologic and renal abnormalities. I report the case of a patient who had severe nail dystrophy (onycholysis) with captopril therapy for renovascular hypertension.
A 61-year-old white woman presented in July 1983 with poorly controlled hypertension. She was taking metoprolol, 100 mg twice daily; hydralazine, 50 mg twice daily; and hydrochlorothiazide, 50 mg once daily. Renal artery stenosis was documented and treated successfully with angioplasty. Her blood pressure rose to unacceptable levels 5 months later, however, despite resumption of similar triple-drug therapy. The patient
BORDERS JV. Captopril and Onycholysis. Ann Intern Med. ;105:305–306. doi: 10.7326/0003-4819-105-2-305_2
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Published: Ann Intern Med. 1986;105(2):305-306.
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