WILLIAM A. BANKS, M.D.; ABBA J. KASTIN, M.D.; EDWARD A. MICHALS
To the editor: Cook and Boyle (1) have recently emphasized the issue of a differential response of the central nervous system to thyroxine and triiodothyronine. Although differential responses of tissues to thyroid hormones may occur at many levels, the hormones must first reach the target organ. In the case of the brain, this means traversing the blood-brain barrier. Triiodothyronine has been shown to be transported across the blood-brain barrier by a saturable, carrier-mediated transport system (2), but by extrapolation it has been widely assumed that thyroxine is transported by the same system. Studies of thyroid levels in the cerebrospinal fluid
BANKS WA, KASTIN AJ, MICHALS EA. Selective Transport Across the Blood-Brain Barrier. Ann Intern Med. ;105:472. doi: 10.7326/0003-4819-105-3-472_1
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Published: Ann Intern Med. 1986;105(3):472.
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