JAMES L. ACHORD, M.D.
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To the editor: A substance that could be used to stimulate the release of vasoactive intestinal polypeptide (VIP) from tumors in the same way we use secretin or calcium to stimulate release of gastrin in gastrinomas would be interesting and potentially useful. We have recently tested the response to a bolus injection of secretin and cholecystokinin (pancreozymin) in a patient with high serum levels of VIP (range, 200 to 600 pg/ mL) and the pancreatic cholera syndrome.
This patient had malignant carcinoid cells recovered by needle aspiration from hepatic nodules and a step-up in serum VIP levels across the hepatic
JAMES L. ACHORD. Secretin, Cholecystokinin, and Vasoactive Intestinal Polypeptide in Pancreatic Cholera. Ann Intern Med. 1986;105:632–633. doi: 10.7326/0003-4819-105-4-632_3
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Published: Ann Intern Med. 1986;105(4):632-633.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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