DAVID M. RODMAN, M.D.; MICHAEL HANLEY, M.D.; POLLY PARSONS, M.D.
To the editor: Aminoglutethimide is an adrenal and peripheral blocker of steroid metabolism that has seen increasing use as a medical alternative to adrenalectomy. It has proved effective as therapy for patients with metastatic breast and prostate carcinomas, as well as those with functioning adrenal tumors (1). Adverse effects are usually transient and mild; however, serious adverse effects including bone marrow suppression, cholestasis, and systemic lupus erythematosus have been reported (2-4). We report a case of diffuse alveolar damage and hemorrhage associated with this drug.
A 47-year-old man with a known islet-cell tumor secreting corticotropin-releasing factor was started on aminoglutethimide,
RODMAN DM, HANLEY M, PARSONS P. Aminoglutethimide, Alveolar Damage, and Hemorrhage. Ann Intern Med. ;105:633. doi: 10.7326/0003-4819-105-4-633_1
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Published: Ann Intern Med. 1986;105(4):633.
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