D. R. R. WILLIAMS
To the editor: Raskin and Rosenstock (1) suggest that around 25% of patients with diabetes have, as a result of genetic factors, a low risk for diabetic complications, whereas a further 5% may be genetically predisposed to develop these complications even when exposed to only a moderate degree of hyperglycaemia. Methods of distinguishing these groups before the onset of complications are currently not available.
Pedigree data collected as part of a genetic and epidemiologic study of diabetes in northern England (2) suggest that the occurrence of diabetes in family members of insulin-treated patients, irrespective of whether the affected relatives are
WILLIAMS DRR. Family History and the Risk of Complications in Diabetes Mellitus. Ann Intern Med. ;105:795. doi: 10.7326/0003-4819-105-5-795_1
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Published: Ann Intern Med. 1986;105(5):795.
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