MITCHELL A. LAZAR, M.D., Ph.D.
To the editor: The findings reported by Hennessey and colleagues (1) in the July issue are not new, and the conclusions presented are simplistic and misleading. Ingbar and coworkers (2), Pearce and Himsworth (3), and Rendell and Salmon (4) have previously noted that many patients receiving "therapeutic doses" of oral L-thyroxine had serum thyroxine levels that were above the normal range for patients not taking a thyroxine preparation. Often, serum levels of triiodothyronine were within the normal range and correlated better with clinical status as assessed by symptoms and signs of hyperthyroidism than did the thyroxine levels. Hennessey and colleagues
LAZAR MA. Reevaluation of L-Thyroxine Dosage. Ann Intern Med. ;105:797–798. doi: 10.7326/0003-4819-105-5-797
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Published: Ann Intern Med. 1986;105(5):797-798.
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