ZVI ACKERMAN, M.D.; HEDI ORBACH, M.D.; MOSHE BURSTEIN, M.D.; RAPHAEL BREUER, M.D.
To the editor: Wegener's granulomatosis is a disease of unknown cause that involves the lungs in 94% of patients; paranasal sinuses, nose, and nasopharynx in 91%; and the kidney in 85%. Other sites involved less frequently are the joints, ears, eyes, skin, nervous system, and heart (1). If untreated, the disease is associated with a high mortality rate. Thus, early diagnosis and treatment with cyclophosphamide and prednisone are imperative (1).
Diagnosis of Wegener's granulomatosis requires histologic evidence of both necrotizing vasculitis and granulomata in one or more of the affected sites (1). Lung tissue gives the best yield for histologic
ACKERMAN Z, ORBACH H, BURSTEIN M, BREUER R. Transbronchial Biopsies in Wegener's Granulomatosis. Ann Intern Med. ;105:801–802. doi: 10.7326/0003-4819-105-5-801_2
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Published: Ann Intern Med. 1986;105(5):801-802.
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