DANIEL I. SPRATT, M.D.; JOEL S. FINKELSTEIN, M.D.; LOUIS ST.L. O'DEA, M.B., B.Ch.; THOMAS M. BADGER, Ph.D.; P. NARASIMHA RAO, Ph.D.; JAN D. CAMPBELL, L.P.N.; WILLIAM F. CROWLEY Jr., M.D.
The effect of long-term administration of gonadotropin-releasing hormone (GnRH) for induction and maintenance of sexual maturation was characterized in 23 men with idiopathic hypogonadotropic hypogonadism. Twenty-two men achieved normal adult male serum testosterone concentrations (575 ± 33 ng/dL; p < 0.0001 compared with the baseline mean of 61 ± 6 ng/dL) that were sustained in 21 men for up to 36 months with bolus doses of GnRH varying from 25 to 300 ng/kg body weight administered every 2 hours. Pulsatile luteinizing hormone (LH) secretion occurred in all 23 men, with mean levels of LH (14.7 ± 1.3 mlU/mL) and follicle-stimulating hormone (11.3 ± 1.3 mlU/mL) within or above the normal range for adult men. Mature sperm were observed in the ejaculates of 20 men, with counts ranging from less than 1 x 106 to 96 x 106/mL. Increasing responsiveness of the pituitary-gonadal axis to GnRH was shown in 6 men. Men with idiopathic hypogonadotropic hypogonadism present a useful model to study the onset and maintenance of reproductive function in men.
SPRATT DI, FINKELSTEIN JS, O'DEA LS, BADGER TM, RAO PN, CAMPBELL JD, et al. Long-Term Administration of Gonadotropin-Releasing Hormone in Men with Idiopathic Hypogonadotropic Hypogonadism: A Model for Studies of the Hormone's Physiologic Effects. Ann Intern Med. ;105:848–855. doi: 10.7326/0003-4819-105-6-848
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Published: Ann Intern Med. 1986;105(6):848-855.
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