DANIEL I. SPRATT, M.D.; JOEL S. FINKELSTEIN, M.D.; LOUIS ST.L. O'DEA, M.B., B.Ch.; THOMAS M. BADGER, Ph.D.; P. NARASIMHA RAO, Ph.D.; JAN D. CAMPBELL, L.P.N.; WILLIAM F. CROWLEY Jr., M.D.
The effect of long-term administration of gonadotropin-releasing hormone (GnRH) for induction and maintenance of sexual maturation was characterized in 23 men with idiopathic hypogonadotropic hypogonadism. Twenty-two men achieved normal adult male serum testosterone concentrations (575 ± 33 ng/dL; p < 0.0001 compared with the baseline mean of 61 ± 6 ng/dL) that were sustained in 21 men for up to 36 months with bolus doses of GnRH varying from 25 to 300 ng/kg body weight administered every 2 hours. Pulsatile luteinizing hormone (LH) secretion occurred in all 23 men, with mean levels of LH (14.7 ± 1.3 mlU/mL) and follicle-stimulating hormone (11.3 ± 1.3 mlU/mL) within or above the normal range for adult men. Mature sperm were observed in the ejaculates of 20 men, with counts ranging from less than 1 x 106 to 96 x 106/mL. Increasing responsiveness of the pituitary-gonadal axis to GnRH was shown in 6 men. Men with idiopathic hypogonadotropic hypogonadism present a useful model to study the onset and maintenance of reproductive function in men.
DANIEL I. SPRATT, JOEL S. FINKELSTEIN, LOUIS ST.L. O'DEA, THOMAS M. BADGER, P. NARASIMHA RAO, JAN D. CAMPBELL, et al. Long-Term Administration of Gonadotropin-Releasing Hormone in Men with Idiopathic Hypogonadotropic Hypogonadism: A Model for Studies of the Hormone's Physiologic Effects. Ann Intern Med. 1986;105:848–855. doi: 10.7326/0003-4819-105-6-848
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Published: Ann Intern Med. 1986;105(6):848-855.
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