LAWRENCE J. SPRECHER, M.D.
To the editor: Williams and coworkers' article on long-term renal function in kidney donors (1) is a provoking and logical study; however, certain flaws weaken its validity. To begin with, the title might effectively have focused on the more primary issue of hypertension rather than on renal disease.
Unfortunately, only 17 sibling pairs were studied, a somewhat small number representing at most only 61% of the potential participant pool. Furthermore, the authors elicited follow-up from only 76% of donors (34 of 50). Established clinical epidemiologic theory suggests that a study that purports to follow the natural course of a disease
SPRECHER LJ. Long-Term Renal Function in Kidney Donors. Ann Intern Med. ;105:975. doi: 10.7326/0003-4819-105-6-975_1
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Published: Ann Intern Med. 1986;105(6):975.
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