NINA S. DAVIS, M.D.; AARON SPITAL, M.D.; DONALD E. KAMM, M.D.
To the editor: In healthy unstressed humans or animals, renal function is not significantly affected by nonsteroidal anti-inflammatory drugs (1, 2). When acute renal failure occurs after use of one of these drugs, it is generally attributed to inhibition of prostaglandin synthesis or, less often, to acute interstitial nephritis (2, 3). We report a case of acute renal failure that occurred in a healthy man after a single dose of suprofen, a new proprionic acid derivative (4).
A 47-year-old general surgeon, previously in good health and on no medications, took one 200-mg capsule of suprofen for treatment of a headache.
DAVIS NS, SPITAL A, KAMM DE. Suprofen and Acute Renal Failure. Ann Intern Med. ;105:976–977. doi: 10.7326/0003-4819-105-6-976_3
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Published: Ann Intern Med. 1986;105(6):976-977.
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