V. GEORGOULIAS; D. FOUNTOULI; A. KARVELA-AGELAKIS; G. KOMIS; E. MALLIARAKIS-PINETIDOU; G. ANTONIADIS; K. SAMAKIDIS; X. KONDAKIS; M. PAPAPETROPOULOU; N. ZOUMBOS; O. AXENIDOU; K. MAKRIS; G. SONIDIS
To the editor: The recently described (1) human immunodeficiency virus type 2 (HIV-2) is distinct but related to HIV-1 by its structure and preferential CD4 tropism and cytopathic effect on these cells. The two viruses share a similar genomic organization but differ significantly in terms of nucleotide and animo-acid identity sequence. The gag and pol genes respectively show only a 56% and 60% nucleotide sequence homology and both less than 60% amino-acid identity (2). The overall nucleotide homology of HIV-1 and HIV-2 is about 42% (2). Serologic studies showed that the gag and pol but not the env proteins
GEORGOULIAS V, FOUNTOULI D, KARVELA-AGELAKIS A, KOMIS G, MALLIARAKIS-PINETIDOU E, ANTONIADIS G, et al. HIV-1 and HIV-2 Double Infection In Greece. Ann Intern Med. ;108:155. doi: 10.7326/0003-4819-108-1-155_1
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Published: Ann Intern Med. 1988;108(1):155.
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