P. VALDIVIELSO, M.D.; J. L. ESCOLAR, M.D.; V. CUERVAS-MONS, M.D.; L. A. PULPÓN, M.D.; M. A. S. CHAPARRO, M.D.; P. GONZÁLEZ-SANTOS, M.D.
Changes in lipids and lipoprotein fractions were studied 6 months after a combined heart and liver transplantation in a patient with terminal ischemic heart disease due to homozygous familial hypercholesterolemia. The double transplant was followed by striking decreases in total and low-density-lipoprotein cholesterol levels (- 71% and - 79%) and content of apolipoprotein B in the low-density-lipoprotein fraction (- 74%). There was also an increase in high-density-lipoprotein cholesterol (+ 7.8%). These changes are greater than those reported with portacaval shunt or plasma exchange. Liver transplantation may be considered in selected patients with homozygous familial hypercholesterolemia.
P. VALDIVIELSO, J. L. ESCOLAR, V. CUERVAS-MONS, L. A. PULPÓN, M. A. S. CHAPARRO, P. GONZÁLEZ-SANTOS. Lipids and Lipoprotein Changes After Heart and Liver Transplantation in a Patient with Homozygous Familial Hypercholesterolemia. Ann Intern Med. 1988;108:204–206. doi: 10.7326/0003-4819-108-2-204
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Published: Ann Intern Med. 1988;108(2):204-206.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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