ROGER J. POMERANTZ, M.D.; SUZANNE M. de la MONTE, M.D.; S. PATRICK DONEGAN, M.D.; TERESA R. ROTA, M.A.; MARKUS W. VOGT, M.D.; DONALD E. CRAVEN, M.D.; MARTIN S. HIRSCH, M.D.
Human immunodeficiency virus (HIV) has been detected in cervical secretions from HIV-infected women. We report the isolation of HIV from four cervical biopsy specimens. Cervicitis was shown by immunohistochemical staining in cervical biopsy specimens from four HIV-seropositive women; cervicitis was not found in cervical biopsy specimens from four HIV-seronegative women. We found HIV antigens in monocyte-macrophages and endothelial cells within the submucosa of three of these cervices by specific immunohistochemical staining. Small numbers of HIV-infected cells resembling lymphocytes also were found in the cervical mucosa. The virus was not shown by culture or immunohistochemistry in cervical biopsy specimens from the four HIV-seronegative women. These findings suggest that HIV enters cervical secretions from selected infected cell populations within the cervical tissue. The HIV-infected cells in cervical tissue may be involved in transmission of HIV by heterosexual contact and to neonates born to HIV-infected women.
POMERANTZ RJ, de la MONTE SM, DONEGAN SP, ROTA TR, VOGT MW, CRAVEN DE, et al. Human Immunodeficiency Virus (HIV) Infection of the Uterine Cervix. Ann Intern Med. 1988;108:321–327. doi: 10.7326/0003-4819-108-3-321
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Published: Ann Intern Med. 1988;108(3):321-327.
HIV, Infectious Disease.
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