DAWNA GILCHRIST, M.D.; CHARLES K. CHAN, M.D.
To the editor: Rice and associates (1) have done a well-designed, rigorous clinical trial on one of the common uses of aminophylline. The authors address the question of whether a widely used treatment strategy in acute exacerbation of chronic obstructive pulmonary disease is efficacious. According to their conclusions, supported by an analysis of power of 0.95, we should consider significantly altering our approach. However, we are reluctant to do so on the basis of a trial that includes only 28 patients.
We would like to know how the authors arrived at their power value of 0.95. Specifically, which outcome variables
GILCHRIST D, CHAN CK. Aminophylline and Chronic Obstructive Pulmonary Disease. Ann Intern Med. ;108:488. doi: 10.7326/0003-4819-108-3-488_1
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Published: Ann Intern Med. 1988;108(3):488.
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