JOSHUA WEINSTEIN, M.D.
To the editor: Nordstrom and associates (1) feel that methotrexate may not be able to significantly alter the rate of radiographic progression of joint damage. Their radiologic criteria combine erosions and joint space narrowing. However, joint space narrowing from secondary degenerative changes in a minimally altered cartilage substrate could have been included with the joint space narrowing solely related to rheumatoid arthritis, especially in view of the 40- to 74-year-old range of this population. As such, is separate data available on the number of new erosions developing in previously totally unaffected joints? Furthermore, because it seems that some of these
WEINSTEIN J. Methotrexate in Rheumatoid Arthritis. Ann Intern Med. ;108:640–641. doi: 10.7326/0003-4819-108-4-640_2
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Published: Ann Intern Med. 1988;108(4):640-641.
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