RICHARD C. BECKER, M.D.; JEANNE M. CORRAO, R.N.
To the editor: Intracoronary thrombosis is a critical component in the pathogenesis of acute myocardial infarction and may also participate in atherogenesis. Therefore, intrinsic abnormalities of the hemostatic and fibrinolytic systems have been studied in patients with coronary artery disease. Atherosclerosis impairs local fibrinolysis by altering vascular endothelial cell structure and function. Systemic fibrinolytic mechanisms may also be defective as a result of abnormal tissue plasminogen activator release (1) and increased tissue plasminogen activator inhibitor concentration (1, 2). Von Schacky's article (3) on omega-3 fatty acids cites Barcelli and associates (4) and states ". . . plasma levels of vascular
BECKER RC, CORRAO JM. Marine Omega-3 Fatty Acids and Atherosclerosis. Ann Intern Med. ;108:641. doi: 10.7326/0003-4819-108-4-641_1
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Published: Ann Intern Med. 1988;108(4):641.
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