DEBORAH J. COOK, M.D.; JOHN G. KELTON, M.D.; ANDRZEJ M. STANISZ, M.D.; STEPHEN M. COLLINS, M.D.
In healthy persons, the coccidioidal protozoan, Cryptosporidium, can inhabit the microvillous border of intestinal epithelial cells and cause an acute self-limited diarrhea. In contrast, the protozoan can cause chronic severe secretory diarrhea in immunosuppressed patients ( 1 ).
Somatostatin has controlled diarrhea in patients with Zollinger-Ellison syndrome (2), Werner-Morrison syndrome (3-5) and the carcinoid syndrome (6). We administered somatostatin analogue (SMS-201-995,, Sandoz Pharmaceuticals, , , Dorval, Quebec) to a patient with the acquired immunodeficiency syndrome (AIDS) who was colonized with cryptosporidia and had diarrhea that was refractory to conventional medical therapy.
A 24-year-old heterosexual man with a congenital bicuspid
COOK DJ, KELTON JG, STANISZ AM, COLLINS SM. Somatostatin Treatment for Cryptosporidial Diarrhea in a Patient with the Acquired Immunodeficiency Syndrome (AIDS). Ann Intern Med. ;108:708–709. doi: 10.7326/0003-4819-108-5-708
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Published: Ann Intern Med. 1988;108(5):708-709.
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