WOLFGANG VOGEL, M.D.; HERMANN KATHREIN, M.D.; OTTO DIETZE, M.D.; GERT JUDMAIER, M.D.
To the editor: The hepatic manifestations of Wilson disease can mimic acute, self-limited hepatitis, rarely progressing to fulminant liver failure or chronic liver disease. The rate of progression from fatty changes to cirrhosis shown by histologic studies varies considerably and occurs by one of the two following processes. In some patients, the collapse of parenchyma, and portal and parenchymal fibrosis lead to inactive cirrhosis. In others, liver disease is indistinguishable from chronic active hepatitis (1). Whereas the latter form of hepatic manifestation of Wilson disease has a more ominous prognosis despite adequate treatment, fibrotic liver disease usually has a more
VOGEL W, KATHREIN H, DIETZE O, JUDMAIER G. Ultrasonography in Wilson Disease. Ann Intern Med. ;108:769–770. doi: 10.7326/0003-4819-108-5-769_2
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Published: Ann Intern Med. 1988;108(5):769-770.
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