PETER J. GOADSBY, M.B.B.S., Ph.D.; LARS EDVINSSON, M.D., Ph.D.; PAUL S. HABER, M.B.B.S.
To the editor: The combination of diarrhea, paroxysmal flushing, and right-sided valvular heart disease is well recognizedas the carcinoid syndrome. The association of both the diarrhea and cardiac disease with elevated levels of serotonin has been well recognized, although the cause of the flushing has never been clarified (1). Both serotonin and substance P levels have been shown to be elevated in peripheral venous blood samplesfrom patients with the carcinoid syndrome (2), although somatostatin has been successfully used to treat flushing (3), suggesting a humoral basis for this manifestation. The study of a possible role for neuropeptides in carcinoid syndrome
GOADSBY PJ, EDVINSSON L, HABER PS. Vasoactive Peptides and the Carcinoid Syndrome. Ann Intern Med. ;108:904. doi: 10.7326/0003-4819-108-6-904_1
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Published: Ann Intern Med. 1988;108(6):904.
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