LUC VERRESEN, M.D.; MARC WAER, M.D.; RENÉ VERBERCKMOES, M.D.; PAUL MORIAS, M.D.; PAUL MICHIELSEN, M.D.
We report the case of a patient with primary sclerosing cholangitis associated with membranous nephropathy.
A 41-year-old man had edema and fatigue. Serum albumin was 9.9 g/L (normal, 36 to 53) creatinine, 109.7 µmol/L (normal, 61 to 119); creatinine clearance, 77.6 mL/min; alkaline phosphatase, 680 U/L (normal, 40 to 130); gamma-glutamyl transpeptidase, 730 U/L (normal, 5 to 24); and a 4+ test for immune complexes (rheumatoid arthritis factor binding assay). Urine analysis showed proteinuria (20 g/d) and 44 dysmorphic erythrocytes/mm3. Tests for mitochondrial antibodies and hepatitis B surface antigen (HBsAg) were negative.
A renal biopsy was done. The only abnormal
VERRESEN L, WAER M, VERBERCKMOES R, MORIAS P, MICHIELSEN P. Primary Sclerosing Cholangitis Associated with Membranous Nephropathy. Ann Intern Med. ;108:909–910. doi: 10.7326/0003-4819-108-6-909_2
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Published: Ann Intern Med. 1988;108(6):909-910.
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