MARSHALL D. LINDHEIMER, M.D.; WILLIAM M. BARRON, M.D.
To the editor: Shubiger and colleagues (1) have confirmed that administering angiotensin-converting enzyme inhibitors to pregnant women can provoke renal failure in the newborn. However, why did they merely conclude that "angiotensin enzyme inhibitors such as enalapril may do limited [italics ours] harm to the fetus as long as the mother takes care of metabolism and excretion," rather than firmly stating that these drugs were contraindicated in gestation?
Reports associating angiotensin-converting enzyme inhibition with fetal death in several animals species appeared as early as 1981 (2-4), prompting one of us to report (5) that this class of drugs should not
LINDHEIMER MD, BARRON WM. Enalapril and Pregnancy-Induced Hypertension. Ann Intern Med. ;108:911. doi: 10.7326/0003-4819-108-6-911_1
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Published: Ann Intern Med. 1988;108(6):911.
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