HUGO RAMS, M.D.; ARVEY I. ROGERS, M.D.; LATIFA GHANDUR-MNAYMNEH, M.D.
Two hypotheses have been proposed to explain the pathogenesis and cause of the increased subepithelial collagen deposition that occurs in patients with collagenous colitis, a rare disease of unknown cause. One hypothesis considers an inflammatory origin, and the other, a local abnormality of collagen synthesis. An analysis of clinical, endoscopic, and histologic findings from one of our patients and from previously published cases suggests that collagenous colitis is a form of inflammatory bowel disease characterized by localization of the initial injury to the superficial subepithelial zone and with subsequent fibrosis in that area. The data show a spectrum of clinical and histologic changes that represent different stages in the evolution of the inflammatory process.
RAMS H, ROGERS AI, GHANDUR-MNAYMNEH L. Collagenous Colitis. Ann Intern Med. 1987;106:108–113. doi: 10.7326/0003-4819-106-1-108
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Published: Ann Intern Med. 1987;106(1):108-113.
Gastroenterology/Hepatology, Inflammatory Bowel Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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