DORON GARFINKEL, M.D.; FREDERIC GLAZENER, M.D.; BRIAN B. HOFFMAN, M.D.
To the editor: Monitoring serum drug concentrations has contributed to the more rational use of drugs. The most important of the laboratory methods currently used for routine drug determinations are immunoassays and those based on high-performance ligand chromatography (HPLC). These methods do not establish the structure of the drug being measured. In an HPLC assay, the elution time of a drug from the column is typically used to identify it. However, the elution time is not necessarily unique to one drug, and a potential for error exists when another compound coelutes with the drug. We report a case in which
GARFINKEL D, GLAZENER F, HOFFMAN BB. Metronidazole Interferes with Theophylline Measurements. Ann Intern Med. 1987;106:171. doi: 10.7326/0003-4819-106-1-171_1
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Published: Ann Intern Med. 1987;106(1):171.
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