AUDREY G. KRIEGMAN, M.D.
To the editor: In his editorial in the March 1986 issue, Dr. Abrams (1) failed to mention the results of several recent acute and chronic dose studies that showed lack of tolerance to transdermal nitroglycerin.
In a double-blind study Scardi and colleagues (2) evaluated the acute effects of two doses of Transderm-Nitro (nitroglycerin; Ciba Pharmaceutical Co., Summit, New Jersey) at 4 and 24 hours after patch application in 15 patients with stable, exercise-induced angina. In comparison with placebo, both doses of Transderm-Nitro (10 and 20 mg/24 h) produced a statistically significant increase (p < 0.01) in exercise duration to 1-mm
KRIEGMAN AG. Transdermal Nitroglycerin and Nitrate Tolerance. Ann Intern Med. ;106:325–326. doi: 10.7326/0003-4819-106-2-325
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Published: Ann Intern Med. 1987;106(2):325-326.
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