C. F. VAN DER MERWE
To the editor: To the hypotheses listed by Raskin and Rosenstock (1) in their recent review on blood glucose control and diabetic complications, I would like to offer a fourth. This hypothesis seems to be in the process of being supported by clinical findings and could have important implications for diabetic therapy.
Diabetes is characterized by hyperglycemia, which is a known inhibitor of the enzyme delta-6-desaturase (2). Chronic inhibition of this enzyme will therefore lead to a reduced production of eicosanoids from the parent essential fatty acids, linoleic acid and alpha-linolenic acid. Eicosanoids have been recognized in recent times as
C. F. VAN DER MERWE. Blood Glucose Control and Diabetic Complications. Ann Intern Med. 1987;106:331–332. doi: 10.7326/0003-4819-106-2-331_2
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Published: Ann Intern Med. 1987;106(2):331-332.
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