N. STANLEY NAHMAN Jr, M.D.; FERNANDO G. COSIO, M.D.; SETH KOLKIN, M.D.; JERRY R. MENDELL, M.D.; HARI M. SHARMA, M.D.
Cyclosporine is an immunosuppressant used primarily in transplantation (1) and more recently in the therapy of autoimmune disease (2, 3). Nephrotoxicity is a well-recognized complication of cyclosporine and includes functional and anatomical damage (1-6). We report the cases of two patients given cyclosporine for immunologic diseases other than major organ transplantation. Both patients developed irreversible renal functional impairment and had renal biopsy findings consistent with chronic cyclosporine nephrotoxicity.
Patient 1: A 25-year-old white woman with a history of congenital glaucoma and recurrent cataracts required several corneal transplants. In July 1984, after bilateral corneal graft placement, the patient was given cyclosporine,
N. STANLEY NAHMAN, FERNANDO G. COSIO, SETH KOLKIN, JERRY R. MENDELL, HARI M. SHARMA. Cyclosporine Nephrotoxicity Without Major Organ Transplantation. Ann Intern Med. 1987;106:400–402. doi: 10.7326/0003-4819-106-3-400
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Published: Ann Intern Med. 1987;106(3):400-402.
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