ALAN S. NIES, M.D.; JOSEPH GAL, Ph.D.
To the editor: We noted with interest the article and accompanying editorial regarding the implementation of SI units in American medical journals (1, 2). Although the arguments are reasonable for the use of these units to describe the concentration of endogenous substances, SI units make less sense when applied to drugs. As long as drugs are administered in mass units, concentrations of drugs in the blood should be in mass/L so that clinicians may use the pharmacokinetic parameters of apparent volume of distribution (VD) and clearance to calculate appropriate loading and maintenance schedules of drugs for their patients (3). The
NIES AS, GAL J. Implementation of SI Units. Ann Intern Med. 1987;106:642. doi: 10.7326/0003-4819-106-4-642_2
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Published: Ann Intern Med. 1987;106(4):642.
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