DAVID S. BARDENSTEIN, M.D.; NORMAN N. K. KATZ, M.D.; DAVID S. FRIENDLY, M.D.; MARSHALL M. PARKS, M.D.
To the editor: A survey of major pediatrics and neonatology textbooks shows few recommendations concerning the need for immediate referral of infants, toddlers, and children with abnormal pupillary reflexes (leukocoria). The differential diagnosis of childhood leukocoria includes various conditions of which the most important are retinoblastoma, cataract, persistent hyperplastic primary vitreous (PHPV), retinal detachment, infections, and inflammations.
The prognosis for life in patients with retinoblastoma is directly related to the size and degree of extension of the tumor and thus to the promptness with which the disease is recognized. The great improvement in survival of patients with retinoblastoma has been
BARDENSTEIN DS, KATZ NNK, FRIENDLY DS, PARKS MM. Pupillary Abnormalities: Light and Sight. Ann Intern Med. ;106:643. doi: 10.7326/0003-4819-106-4-643_2
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Published: Ann Intern Med. 1987;106(4):643.
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