ROBERT E. ENCK, M.D.
To the editor: The observation by Overly and Jakubek (1) regarding the association of multiple squamous cell carcinomas of the skin and a positive serologic test for human immunodeficiency virus (HIV) in a factor-IX-deficient man is interesting but raises an important question regarding the causal relationship. The authors attribute the HIV serologic positivity to treatment with factor IX concentrates over a period of many years.
Before the onset of the acquired immunodeficiency syndrome (AIDS) epidemic, we extensively studied (2, 3) a group of patients with hereditary bleeding disorders (factor VIII deficiency, factor IX deficiency, and von Willebrand disease) at the
ENCK RE. Squamous Cell Cancers and the Acquired Immunodeficiency Syndrome. Ann Intern Med. 1987;106:773. doi: 10.7326/0003-4819-106-5-773_1
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Published: Ann Intern Med. 1987;106(5):773.
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