BERTRAND DUPONT, M.D.; EDOUARD DROUHET, M.D.
To the editor: We report a case of cryptococcal meningitis in a patient with the acquired immunodeficiency syndrome (AIDS) that was cleared by oral fluconazole. The patient is doing well on a maintenance therapy with this new azole derivative developed by Pfizer Central Research, Kent, England (1, 2).
A 27-year-old man with positive antibodies for the human immunodeficiency virus (HIV) had cryptococcal meningitis in January 1986. Treatment with intravenous amphotericin B 30 to 40 mg every second day, and oral flucytosine, 100 mg/kg body weight · d all resolved symptoms, and culture from cerebrospinal fluid became negative. However, granulocytopenia developed
DUPONT B, DROUHET E. Cryptococcal Meningitis and Fluconazole. Ann Intern Med. ;106:778. doi: 10.7326/0003-4819-106-5-778_2
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Published: Ann Intern Med. 1987;106(5):778.
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