WILLIAM J. FLYNN, M.D.; PAMELA G. FREEMAN, M.D.; LLOYD G. WICKBOLDT, M.D.
Isotretinoin (Accutane; Roche Laboratories, Nutley New Jersey) is a vitamin A derivative useful in the treatment of skin disorders caused by follicular occlusion. Isotretinoin is most frequently prescribed for recalcitrant nodulocystic acne ( 1 ). Elevation of the serum triglyceride level has been previously reported (2). We report a case of pancreatitis precipitated by hypertriglyceridemia associated with isotretinoin therapy.
A 43-year-old white woman had a 10-year history of nodulocystic acne and hidradenitis suppurativa refractory to oral tetracyclines and topical therapy. Isotretinoin had been instituted at 40 mg orally twice daily (1.0 mg/kg bodyweight · d) after baseline fasting laboratory studies
FLYNN WJ, FREEMAN PG, WICKBOLDT LG. Pancreatitis Associated with Isotretinoin-lnduced Hypertriglyceridemia. Ann Intern Med. ;107:63. doi: 10.7326/0003-4819-107-1-63
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Published: Ann Intern Med. 1987;107(1):63.
Cardiology, Coronary Risk Factors, Dyslipidemia, Gastroenterology/Hepatology, Pancreatic Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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