THOMAS FEKETE, M.D.; DAVID GARY SMITH, M.D.
To the editors: In their article comparing the treatment of renal infections with ampicillin or trimethoprim-sulfamethoxazole in 2- or 6-week courses, Stamm and colleagues (1) have blurred the distinction between two very different hypotheses: that longer courses or different antibiotics prevent relapse with the same organism, and that antibiotics prevent reinfections with new organisms during or after antibiotic therapy. We agree that they and others have shown that longer courses can prevent relapse (2). However, we have several questions about their conclusions concerning the prevention of reinfection by antibiotics.
First, should both groups have been followed for the same period
FEKETE T, SMITH DG. Relapse and Reinfection in Acute Pyelonephritis. Ann Intern Med. 1987;107:114–115. doi: 10.7326/0003-4819-107-1-114_2
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Published: Ann Intern Med. 1987;107(1):114-115.
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