JOHN J. AMBRE, M.D.; R. SMITH-COGGINS, M.D.; STEVEN BELKNAP, M.D.; JOHN NELSON, M.D.
To the editor: It is well known that the ideal intravenous drug regimen designed to achieve immediately and then maintain a constant plasma drug concentration is a loading dose injection followed by an infusion that exponentially decreases to a constant maintenance rate. The major obstacle to the application of the ideal regimen in the clinical setting has been the lack of a simple, economical method of effecting exponential drug delivery. Exponentially decreasing intravenous infusions have been approximated by stepped changes in delivery rate from constant rate infusion pumps, multiple injection loading doses, and other methods (1, 2), which have the
AMBRE JJ, SMITH-COGGINS R, BELKNAP S, NELSON J. A Technique for Producing Constant Plasma Drug Concentrations. Ann Intern Med. ;107:122. doi: 10.7326/0003-4819-107-1-122_1
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Published: Ann Intern Med. 1987;107(1):122.
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